Exercise helps restore brain insulin sensitivity, a new study indicates. In a study of 21 healthy males and females with BMIs between 27.5 and 45.5, researchers measured insulin sensitivity in the brain by functional magnetic resonance imaging (fMRI). This was done before and after an eight-week exercise intervention. Then, the participants completed an OGTT test two days later.
The results of the study show that eight weeks of physical activity can restore brain insulin sensitivity in severely overweight adults. This is an important discovery for patients suffering from obesity or type 2 diabetes. Insulin resistance affects a person’s metabolism and eating behavior and is one of the leading risk factors for both conditions.
Insulin nasal spray, administered into the nose, increases cerebral blood flow in the striatum and right putamen. However, the treatment had no effect on other insulin-sensitive brain regions. This study showed that insulin nasal spray increased CBF in the right putamen and striatum, but not in other regions.
A moderate to vigorous aerobic exercise program may improve insulin sensitivity. In particular, a combination of aerobic and resistance exercise is beneficial. This type of exercise involves engaging the heart and lower body muscles and raising the heart rate for long periods of time. Muscle is a metabolically high tissue, and requires a large amount of energy to repair itself.
Exercise-induced changes in brain insulin action may be associated with changes in peripheral metabolism and perceived hunger. The correlations between these changes are reflected in mediation analyses. By testing the mechanism behind the observed relationships, researchers looked at measures of peripheral metabolism, such as the amount of VAT in skeletal muscle fibers.
Brain insulin sensitivity restored through exercise – The Next Level - The Next Level
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