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Thursday, December 23, 2021

COVID-19 News: Simcoe Muskoka logs 229 new COVID-19 cases - CTV News Barrie

Simcoe Muskoka logged the region's highest single-day COVID-19 case count of the pandemic, with more than 200 new infections.

The health unit posted 229 new cases on Thursday, one day after the region's medical officer of health said he wasn't sure if or when the pandemic would end.

"The course of the pandemic has been discouraging, to say the least, and I don't actually have a clear vision as to exactly when and how it will end," Dr. Gardner said during a virtual COVID-19 update on Wednesday.

The region hit 1,647 active infections, including 30 hospitalizations, with eight patients admitted to ICUs.

"Confirmed cases underestimate the true number of people with COVID-19," the Simcoe Muskoka District Health Unit (SMDHU) stated.

"The current demand for lab-based PCR COVID-19 testing has exceeded capacity, and this in conjunction with other biases (e.g. limited testing of asymptomatic individuals) can contribute to underestimating COVID-19 transmission in our communities," SMDHU noted on its website.

Weekly case counts have increased more than 50 per cent recently, as the highly contagious Omicron variant starts to dominate cases.

"I think it's important to realize that Omicron is much more transmissible," Dr. Gardner added.

There have been 60 Omicron cases identified in Simcoe Muskoka to date, according to the SMDHU.

The region's top doctor stressed the importance of vaccination and self-isolating if exhibiting symptoms.

No virus-related deaths were reported on Thursday. To date, the health unit reports 286 residents passed away after contracting COVID-19.

Of the cases reported in the past 24 hours, 162 are breakthrough infections.

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COVID-19 News: Simcoe Muskoka logs 229 new COVID-19 cases - CTV News Barrie
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Pop-up site at Mohawk College to administer up to 1,000 tests per day: Hamilton public health - CBC.ca

A new temporary pop-up testing site opened at Mohawk College on Thursday to support additional testing in the city, Hamilton public health said.

The health unit said the site can administer up to 1,000 tests per day and will operate seven days a week, eight hours a day.

"The pop-up testing site will add support to Hamilton's two assessment centres — St. Joe's Mountain Testing Centre on Upper James and Hamilton Health Sciences COVID-19 Assessment Centre in the west end," the health unit said.

"The three locations combined will provide up to 2,700 individual tests daily."

According to the health unit, the demand for testing in Hamilton, as with many regions, is beyond current capacity. Currently, those seeking testing as symptomatic or close contacts of COVID-19 positive individuals are booking many days out, and often there are no appointments available, it said.

Resident are reminded that in keeping with provincial guidelines, appointments must be made in advance for all testing sites. No walk-ins will be permitted at any Hamilton COVID-19 testing facility. 

Residents are also reminded that if they are experiencing COVID symptoms or are a close contact of a COVID-positive individual, to follow public health guidelines to isolate in order to limit the spread of COVID-19.

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Pop-up site at Mohawk College to administer up to 1,000 tests per day: Hamilton public health - CBC.ca
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Human connections: 'Friendly Calls' program reaches out to lonely, isolated Canadians - CHEK

HALIFAX — Wendy Goodall moved from Ontario to the sprawling prairies of southern Saskatchewan two years ago. Then the COVID-19 pandemic shrank her world.

“I knew nobody here, except my daughter and her family,” says Goodall, a widow in her early 70s who lives in the village of Lipton, Sask. “If I was to get COVID, my doctor said I wouldn’t survive it. It’s very depressing not to be able to get out.”

As the pandemic dragged on, Goodall’s deepening sense of loneliness prompted a counsellor to refer her to a free program established by the Canadian Red Cross in early 2020, as the spread of the virus led to lockdowns across the country.

The Friendly Calls program pairs participants like Goodall with trained Red Cross volunteers who typically call once a week to chat. As simple as it seems, the program — offered in French and English — has proven to be so popular that it has expanded to every province and the Northwest Territories.

“To have that phone call and be able to talk to somebody, it’s super,” says Goodall, who has been talking regularly to the same volunteer in Saskatchewan since September. “If I didn’t have the phone call, I wouldn’t talk to anybody during the week.”

In the past six months, the program has logged more than 30,000 calls involving 500 volunteers and 3,000 clients, says Chris Baert-Wilson, a Red Cross director based in Halifax and leader of the Friendly Calls program.

“We started in the depths of the COVID-19 pandemic, acknowledging that people were isolating — and even if they weren’t isolating, they weren’t able to travel,” she said in an interview. “And a lot of folks haven’t seen family members in a very long time. People are feeling out of sorts, isolated and alone.”

Most of the participants, who must be at least 18 years old, are seniors. Some clients want brief check-ins, others seek a more meaningful connection. In every case, volunteers are matched with clients based on shared interests, a key feature that Goodall has come to appreciate.

“The lady that I have been talking to, she has been a gardener like myself,” says Goodall. “So we talk about plants.”

But Goodall is quick to note their conversations can go much deeper than that. “She called me one day and I was quite upset. I was able to talk it out with her. By the end of the conversation, I had a smile back on my face.”

For more complex cases, the volunteers can help clients find the resources they need to meet their physical and mental health needs, Baert-Wilson says.

“What we’re finding is that the volunteers and the clients are both getting a lot out of it,” she says, adding that the Red Cross is looking for more volunteers. “They really are developing friendships and relationships.”

Roberta Derosier, a Friendly Calls volunteer for the past 18 months, was matched last year with a senior who was living alone on a farm in rural Saskatchewan.

“Her and I both come from a dairy farm background,” Derosier said in an interview from her home in Estevan, Sask. “We were able to bond right away over that.”

More recently, the older woman had to move to a long-term-care facility, where she sometimes struggles with memory lapses caused by dementia.

“But when we’re talking about farming, it all comes back,” Derosier says, adding that their calls now include video chats. “When we actually got to see each other, it was incredible. She had tears when she could actually see who she was talking to.”

Without that kind of companionship and emotional support, older people are particularly vulnerable to mental decline, says Dr. Simon Sherry, a professor in the department of psychology and neuroscience at Dalhousie University in Halifax.

“When we deprive our elderly of social interactions, there are corresponding harms with their cognitive health,” he said, referring to health protection measures that have kept people isolated.

“Something like a phone call and the human connection that it provides is enormously important. Humans are social animals. We need belongingness and connection in order to be well.”

A 2010 study by the American Psychological Association concluded that prolonged isolation carries the same health risks as smoking 15 cigarettes per day.

But it would be a mistake to think the perceived widespread loneliness and social isolation that gave rise to the Friendly Calls program is a new phenomenon, Sherry said. There’s plenty of evidence to suggest loneliness has been on the rise in Western societies for quite some time.

“Canadians were already lonely,” Sherry said, adding that the proliferation of personal computers, smartphones and video games have contributed to social disconnection. “We have for some time been living in a state of social and emotional deprivation.”

Soon after the pandemic was declared and punishing lockdowns were imposed, however, younger Canadians turned to texting, social media and video conferencing to maintain their social connections. The problem is that these technologies do not appeal to most seniors, Sherry said. That’s why the strength of Friendly Calls program may be in its simplicity.

An evaluation of the program after one year of operation found participants were feeling better, both mentally and physically.

“They had something to look forward to,” said Baert-Wilson, who is also the Red Cross’s director of community health for Atlantic Canada. “One lady said even though she was talking to a volunteer over the phone, it made her feel like having to get up out of bed and get dressed.”

This report by The Canadian Press was first published Dec. 23.

Michael MacDonald, The Canadian Press

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Human connections: 'Friendly Calls' program reaches out to lonely, isolated Canadians - CHEK
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Wednesday, December 22, 2021

Grey Bruce Health Unit Shifts COVID-19 Case & Contact Management Focus - Bayshore Broadcasting News Centre

Public Health Grey Bruce says following provincial direction, COVID-19 case and contact-management will now focus on high-risk settings like hospitals, Long-Term Care and Retirement Homes and other vulnerable congregate care settings such as shelters.

A release from the Health Unit says, “Over and above the provincial direction, the Grey Bruce Health Unit will continue to contact all cases in Grey Bruce to inform them of positive results, and conduct an initial assessment. Our local team will also do a thorough risk assessment, and cases and contacts management for individuals associated with high-risk settings. Individuals not deemed at high-risk will be referred for follow-up provincially.”

The Health Unit says it is echoing Ontario’s Chief Medical Officer of Health Dr. Kieran Moore’s statement Tuesday which said, “As cases continue to rise at a rapid rate, the provincial workforce will be reaching out to those who have tested positive and asking them to notify their close contacts directly. If you receive that call, please follow the isolation recommendations. Cases that are not in high-risk settings will be provided with details on testing and isolation, and instructions on how to identify and inform their close contacts. Household contacts of positive cases need to stay home and isolate, regardless of their vaccination status.”

The Grey Bruce Health Unit says it has updated its website and has developed a guidance document for all confirmed cases, contacts, or anyone who is concerned about being positive with COVID-19. Changes are highlighted and linked in the alert box at the top of the homepage at https://ift.tt/2QR9RdS

It says, “As we are operating at enhanced capacity for both case and contact management and vaccine rollout, we are asking the public to please limit calling our helpline for general information. All information can be found on the Grey Bruce Health Unit’s website including information about the updated process on testing and case management.”

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Grey Bruce Health Unit Shifts COVID-19 Case & Contact Management Focus - Bayshore Broadcasting News Centre
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UBC scientists unveil world's first molecular-level analysis of Omicron variant spike protein - UBC News

Findings show strong antibody evasion and binding with human cells that contribute to increased transmissibility—and that vaccination remains the best defence

UBC researchers are the first in the world to conduct a molecular-level structural analysis of the Omicron variant spike protein.

The analysis—done at near atomic resolution using a cryo-electron microscope—reveals how the heavily mutated variant infects human cells and is highly evasive of immunity. The findings shed new light on why Omicron is highly transmissible and will help accelerate the development of more effective treatments.

Dr. Sriram Subramaniam (he/him), professor in UBC faculty of medicine’s department of biochemistry and molecular biology, discusses the implications of his team’s research, which is currently under peer review and available as a preprint at bioRxiv.

What did you examine with this study?

Dr. Sriram Subramaniam

Dr. Sriram Subramaniam

The Omicron variant is unprecedented for having 37 spike protein mutations—that’s three to five times more mutations than any other variant we’ve seen.

This is important for two reasons. Firstly, because the spike protein is how the virus attaches to and infects human cells. Secondly, because antibodies attach to the spike protein in order to neutralize the virus. Therefore, small mutations on the spike protein have potentially big implications for how the virus is transmitted, how our body fights it off, and the effectiveness of treatments.

Our study used cryo-electron microscopy and other tests to understand how mutations impact the behaviour of the Omicron variant at a molecular level.

What does your analysis reveal?

We see that several mutations (R493, S496 and R498) create new salt bridges and hydrogen bonds between the spike protein and the human cell receptor known as ACE2. This appears to increase binding affinity—how strongly the virus attaches to human cells—while other mutations (K417N) decrease the strength of this bond.

Overall, the findings show that Omicron has greater binding affinity than the original SARS-CoV-2 virus, with levels more comparable to what we see with the Delta variant. It is remarkable that the Omicron variant evolved to retain its ability to bind with human cells efficiently despite such extensive mutations.

What about the effectiveness of antibodies?

Our experiments confirm what we’re seeing in the real world—that the Omicron spike protein is far better than other variants at evading monoclonal antibodies that are commonly used as treatments, as well as at evading the immunity produced by both vaccines and natural infection.

Notably, Omicron was less evasive of the immunity created by vaccines, compared to immunity stemming from natural infection in unvaccinated COVID-19 patients. This suggests that vaccination remains our best defence against the Omicron variant.

What do these molecular-level changes tell us about the macro behaviour of the Omicron variant?

Both the characteristics we see as a result of spike protein mutations—strong binding with human cells and increased antibody evasion—are likely contributing factors to the increased transmissibility of the Omicron variant. These are the underlying mechanisms fuelling the variant’s rapid spread and why Omicron could become the dominant variant of SARS-CoV-2 very quickly.

How do we treat a variant that is so effective at evading immunity?

The good news is that knowing the molecular structure of the spike protein will allow us to develop more effective treatments against Omicron and related variants in the future. Understanding how the virus attaches to and infects human cells means we can develop treatments that disrupt that process and neutralize the virus.

An important focus for our team is to understand better the binding of neutralizing antibodies and treatments that will be effective across the entire range of variants, and how those can be used to develop variant-resistant treatments.

Interview language(s): English

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UBC scientists unveil world's first molecular-level analysis of Omicron variant spike protein - UBC News
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The Winnipeg Foundation Innovation Fund supports cutting-edge projects - UM Today

February 1, 2024 —  Three interdisciplinary teams from the Rady Faculty of Health Sciences have received $100,000 grants from The Winnipeg...