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Tuesday, January 2, 2024

Canada's lack of public data about pediatric flu numbers leaves pediatricians 'flying blind' - The Globe and Mail

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A sign directs visitors to the emergency department at CHEO in Ottawa, on May 15, 2015.Adrian Wyld/The Canadian Press

At least two children have died in Canada after contracting influenza in recent weeks, but Ottawa has so far not released any data on how flu season is affecting pediatric patients across the country – a situation clinicians say is leaving them in the dark and may be compromising the response to emerging problems.

“It’s really concerning that we don’t know what’s going on,” said Manish Sadarangani, a pediatric infectious diseases specialist. “I sort of feel like we’re flying blind.”

“It really helps to know what infections are currently circulating and which infections are causing more severe illness and hospitalization in children,” said Ashley Roberts, a clinical assistant professor of pediatric infectious diseases at the University of British Columbia.

“To not have that active data present for our clinical care is certainly a loss right now,” Dr. Roberts added.

Each week, the Public Health Agency of Canada publishes a FluWatch report that details influenza trends across the country. Last season, for instance, the report helped pediatricians understand and respond to soaring rates of hospital admission for the flu at a time when COVID-19 and respiratory syncytial virus (RSV) were also sickening many kids across Canada.

‘We’re actually quite worried:’ Spike in children, babies with respiratory virus symptoms in Western Canada

But as of Oct. 1, FluWatch reports have not included any information on the number of children who have fallen severely ill as a result of the flu. The reports simply state the data were “not available.”

The lack of information appears to be the result of a decision by PHAC to put a new group in charge of collecting pediatric data on severe outcomes for respiratory viruses.

On Nov. 1, the agency awarded a new contract to the University of Calgary, PHAC spokesperson Tammy Jarbeau wrote in an e-mail. She said the government is working with the group “on the implementation of the contract and the transition” to ensure the new data will be comparable to information collected in previous years.

According to another PHAC spokesperson, Marie-Pier Burelle, the government received the first cache of data on Nov. 24, and the information is being used internally. It should be made public sometime this month, she wrote in an e-mail.

For more than 25 years, Ottawa had been using the same surveillance network, IMPACT, to collect this data. IMPACT, which stands for Canada’s Immunization Monitoring Program ACTive, is run by the Canadian Paediatric Society and has experts based in 12 pediatric sites, representing 90 per cent of tertiary care pediatric beds in the country.

Dr. Sadarangani, a co-principal investigator of IMPACT, said it’s critical to have data on pediatric respiratory virus outcomes for this season, given that last season hospitals saw an unusually high influx of flu, RSV and COVID-19 cases. And it’s expected that a new vaccine to prevent severe illness in infants with RSV will become available next season, so experts will need detailed information on RSV cases this season to help them determine who should get that vaccine and when, he said.

“We really need that data this year, almost more than ever,” Dr. Sadarangani said.

Dr. Roberts, who is not formally affiliated with IMPACT, said the absence of national pediatric data in recent months has “baffled” her colleagues.

Last month, the BC Centre for Disease Control issued a public warning about the flu after two children, reportedly under age 10, died of complications related to the virus. The agency is urging members of the public to get themselves and their loved ones vaccinated to protect them.

In addition to surveillance on respiratory virus outcomes, IMPACT also collected data on adverse events following immunization, vaccine effectiveness and vaccine-preventable diseases such as chicken pox and whooping cough.

Marie Adèle Davis, executive director of the Canadian Paediatric Society, said the government did not include vaccine-preventable diseases in the terms of its new pediatric surveillance data contract. Instead, PHAC put out a separate solicitation bid for tracking that information, which has yet to be awarded. What worries Ms. Davis is that this suggests there is no network tracking trends on a national level.

“No one is monitoring those diseases right now,” she said.

Ms. Davis noted that the government’s bid solicitation for the data surveillance network removed the requirement that the network be run by pediatric infectious disease specialists and involve nurses. She said IMPACT worked for years to develop a robust process to analyze information to ensure that any new data, such as an adverse event from a vaccine or the presence of a new vaccine-preventable disease, are interpreted correctly.

IMPACT’s data are also used for research purposes, including studies on the impact the pandemic had on pediatric flu admissions or rates of influenza in immunocompromised children.

“It was not simply a program where we collected data and submitted it to government,” she said. “It was really about using that data to inform child and youth health policy.”

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Canada's lack of public data about pediatric flu numbers leaves pediatricians 'flying blind' - The Globe and Mail
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Get tested and stop HIV in it's tracks - CKPGToday.ca

“Prep is pre-exposure prophylaxis for HIV,” explains Brett Chaisson, pharmacy manager, Third Ave pharmacy. “That’s medication that’s provided to people that may or may not be engaging in high risk HIV exposure activities. So, this might prevent an infection before it occurs by them having the antiretroviral oils in their system before being exposed to the virus.”

If you do get HIV you have a variety of treatment processes to prevent it from developing into AIDS. these treatments are retroviral drugs which stops the virus from replicating in the body. Most treatments can be safely used with gender affirming or menopausal hormone therapies. However side effects may occur.

If taken long enough people with HIV will have their viral load decrease to undetectable levels when blood is drawn. This also means their potential to spread the illness is decreased. That being said safe sex is even more important in this case.

“I would definitely say bring up with any potential future partners. Say like, I do have HIV, but maybe my viral load is undetectable or say, your partner is on PrEP than they would, potentially be able to get exposed to the HIV retrovirus and still not contract it,” continues Brett Chaisson.

It is extremely important to get tested because when HIV is caught early the treatment is easier

“According to the research we have for now, it says like 20% of Canadians, they don’t really know whether they have HIV or not,” says Vibusha Madanayake Education Manager, Positive Living North. “It’s really important to get tested regularly. HIV is not anymore a death sentence. So, if you have HIV, then go and meet your family doctor or go for a walk in clinic and meet your nursing practitioner or doctor and get the proper treatment.”

Positive Living north provides testing for HIV and HCV through the Fire Pit Cultural Center.

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reddit: u/Sam_CKPG

Email: sam.bennison@pattisonmedia.com

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Emergency rooms should give opioid users withdrawal meds: study - BarrieToday

Better patient outcomes could be achieved from emergency department visits for opioid overdoses if those visits were used to initiate opioid agonist therapy, says a study published recently in the Canadian Medical Association Journal.

Opioid agonist therapy (OAT) is regarded as helpful for people with an addiction to opioid drugs such as heroin, oxycodone, hydromorphone (Dilaudid), fentanyl and Percocet, said the study. 

The OAT therapy involves taking the opioid agonists methadone (Methadose) or buprenorphine (Suboxone), which are medications that help prevent withdrawal and reduce the cravings for opioid drugs. Advocates for OAT argue this can help people who have Opioid Use Disorder (OUD) by stabilizing their lives and reducing harms.

The Health Canada website said with opioid agonist therapy, long-acting opioid medications are given under the supervision of a health care provider. These drugs act more slowly in the body for a longer period of time.

The CMAJ study was authored by Tina Hu, Daniel McCormack, David N. Juurlink, Tonya J. Campbell, Ahmed M. Bayoumi, Pamela Leece, Jessica T. Kent and Tara Gomes representing scientists and physicians at the University of Toronto faculty of medicine, McMaster University department of family medicine, the Sunnybrook Research Institute, Public Health Ontario and the Department of Emergency Medicine (Kent), University of Toronto.

CMAJ said the objective of the study was to evaluate OAT initiation rates after a hospital encounter for opioid toxicity in Ontario emergency rooms and determine whether publication of a 2018 Canadian OUD management guideline was associated with increased initiation.

The study found that after more than 20,700 hospital visits for OUD patients with opioid toxicity, the median age was 35 years and just over 65 per cent of them were males. 

"Among hospital encounters for opioid toxicity, despite rising prevalence over time, only one in 18 patients (in Ontario) were dispensed OAT within a week of discharge in early 2020. These findings highlight missed opportunities to initiate therapies proven to reduce mortality in patients with OUD," said the study.

"Opioid use disorder (OUD) is a substantial public health problem with an increasing prevalence worldwide," said the study. 

From 2016 to 2021, the study said 26,690 opioid-related deaths occurred in Canada. 

Some of the startling facts in the study were that from 2016 to 2021, there were 26,690 opioid-related deaths that occurred in Canada. In Ontario, two-thirds of these deaths were among patients with OUD. The study said that, in 2021, one in 219 Ontarians was treated for OUD.

In Canada, opioid-related hospital admissions increased by 32 per cent between 2016 and 2021.  

Also in Ontario, opioid-related emergency department visits increased by 286 per cent. Among patients presenting to the emergency department with nonfatal opioid overdose, close to five per cent die within one year.

The report concluded that additional efforts are needed across Canada to improve initiation of OAT in acute care settings.

A full text copy of the study is available online here.

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Emergency rooms should give opioid users withdrawal meds: study - BarrieToday
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Monday, January 1, 2024

Study says EDs should be giving opioid users withdrawal meds - BradfordToday

Better patient outcomes could be achieved from emergency department visits for opioid overdoses if those visits were used to initiate opioid agonist therapy, said a study published this week in the Canadian Medical Association Journal (CMAJ).

Opioid agonist therapy (OAT) is regarded as helpful for people with an addiction to drugs such as heroin, oxycodone, hydromorphone (Dilaudid), fentanyl and Percocet, the study said. 

The OAT therapy involves taking the opioid agonists methadone (Methadose) or buprenorphine (Suboxone), which are medications that help prevent withdrawal and reduce the cravings for opioid drugs. Advocates for OAT argue this can help people who have Opioid Use Disorder (OUD) by stabilizing their lives and reducing harms.

The Health Canada website said with opioid agonist therapy, long-acting opioid medications are given under the supervision of a health-care provider. These drugs act more slowly in the body for a longer period of time.

The CMAJ study was authored by Tina Hu, Daniel McCormack, David N. Juurlink, Tonya J. Campbell, Ahmed M. Bayoumi, Pamela Leece, Jessica T. Kent and Tara Gomes representing scientists and physicians at the University of Toronto (U of T) faculty of medicine, McMaster University department of family medicine, the Sunnybrook Research Institute, Public Health Ontario and U of T's Department of Emergency Medicine (Kent).

CMAJ said the objective of the study was to evaluate OAT initiation rates after a hospital encounter for opioid toxicity in Ontario emergency rooms and determine whether publication of a 2018 Canadian OUD management guideline was associated with increased initiation.

The study found that after more than 20,700 hospital visits for OUD patients with opioid toxicity, the median age was 35 years and just over 65 per cent of them were males. 

"Among hospital encounters for opioid toxicity, despite rising prevalence over time, only one in 18 patients (in Ontario) were dispensed OAT within a week of discharge in early 2020. These findings highlight missed opportunities to initiate therapies proven to reduce mortality in patients with OUD," said the study.

"Opioid use disorder (OUD) is a substantial public health problem with an increasing prevalence worldwide," said the study. 

From 2016 to 2021, the study said 26,690 opioid-related deaths occurred in Canada. 

Some of the startling facts in the study were that from 2016 to 2021, there were 26,690 opioid-related deaths that occurred in Canada. In Ontario, two-thirds of these deaths were among patients with OUD. The study said that in 2021 1 in 219 Ontarians was treated for OUD.

In Canada, opioid-related hospital admissions increased by 32 per cent between 2016 and 2021.  

Also in Ontario, opioid-related emergency department visits increased by 286 per cent. Among patients presenting to the emergency department with nonfatal opioid overdose, close to 5 per cent die within one year.

The report concluded that additional efforts are needed across Canada to improve initiation of OAT in acute care settings.

A full text copy of the study is available online here.

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Study says EDs should be giving opioid users withdrawal meds - BradfordToday
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2 children die from flu-related illnesses: B.C. Centre for Disease Control - Kitimat Northern Sentinel

The B.C. Centre for Disease Control says two children have died from complications related to influenza.

The centre is reminding people to take steps to reduce their risk of serious illness, noting the province is currently logging influenza and RSV activity similar to levels recorded before the COVID-19 pandemic.

An advisory posted online by the centre says early findings indicate the two children — who both died in the last two weeks — experienced secondary bacterial infections contributing to severe illness, which can be a complication of the flu.

It says influenza activity in children is currently at the highest levels recorded in British Columbia since the start of this respiratory illness season.

The centre says this year’s influenza vaccine appears to be well matched to the viruses circulating in the province.

It is recommending people get vaccinated, stay home if they are sick and wash their hands regularly.

READ ALSO: COVID-19 cases remain low, but flu and RSV creeping up: B.C. health officer

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2 children die from flu-related illnesses: B.C. Centre for Disease Control - Kitimat Northern Sentinel
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How Saskatchewan’s outlook on COVID-19 changed in 2023 - Global News

Medical professionals say COVID-19 is still circulating in Saskatchewan.

While not as prevalent as it has been in the past, it’s something the Saskatchewan Health Authority is still keeping its eye on.

“We want to make sure that we, as a community, do well as we have in the last few years, preventing COVID-19 illness,” said Dr. Simon Kapaj, a Saskatoon medical health officer with SHA.

According to the province’s latest report from its respiratory illness tracker, there were 569 confirmed COVID-19 cases over the two week reporting period between Dec. 3 and Dec. 16.

It shows 13 intensive care admissions and one death related to the disease over the same timeframe.

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COVID testing ‘breach of trust’: Health-care providers call for accountability after investigation

Doctors are encouraging people to continue protecting themselves from the virus and say the best way to do that is to get vaccinated.

“We have new vaccines, reformulated vaccine, that targets specifically the variants that are circulating now,” said Nazeem Muhajarine, an epidemiology professor at the University of Saskatchewan.

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One Saskatoon pharmacy said it had an early-season rush of people getting their COVID and flu shots.

“We were fully booked for the first three to four weeks, which was great and we’re still booking a few hours per day,” said pharmacist Jaclyn Katelnikoff at Saskatoon Family Pharmacy.

Click to play video: 'COVID-19 variant hits Sask., but expert says ‘no need to panic’'

COVID-19 variant hits Sask., but expert says ‘no need to panic’

But provincial data shows many in Saskatchewan don’t have their vaccinations up to date.

According to the Community Respiratory Illness Surveillance Program (CRISP) report, just 17 per cent of people six months or older have at least one dose of COVID-19 vaccine on or after Sept. 18, when it became available.

It’s a similar trend for flu vaccines, with the report showing 22.5 per cent of the Saskatchewan population has its shot as of Dec. 16.

SHA’s deputy chief medical health officer believes vaccine fatigue could be behind the low numbers.

“We have had lower uptake of both COVID and influenza vaccines compared to years past, so that may point to vaccine fatigue,” Dr. Julie Kryzanowski said.

“I would say that it’s still important for people to take advantage of the publicly funded vaccines that are available to them.”

Click to play video: 'Low vaccine uptake fuels spike in respiratory illnesses: health officials'

Low vaccine uptake fuels spike in respiratory illnesses: health officials

Muhajarine said the virus will continue circulating, but believes it will have a more predictable pattern than it did early on during the pandemic.

“We are seeing high numbers in all the respiratory diseases and that’s what we’ll see for the next three to four months,” Muhajarine said.

Health professionals are reminding people to take precautions, including hand-washing and staying home when sick, to avoid illness.

&copy 2024 Global News, a division of Corus Entertainment Inc.

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How Saskatchewan’s outlook on COVID-19 changed in 2023 - Global News
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These B.C. neuroscientists hope to help people with mental health challenges — using patients' own brainwaves - CBC.ca

A growing number of psychiatrists and psychologists in B.C. say they're successfully treating patients by harnessing the power of patients' own brain waves.

Neurofeedback treatment has been studied for several decades but remains controversial among scholars.

"This debate has been going on for a long time," said Simon Fraser University neuroscientist Randy McIntosh.

"There is a long history of using things like neurofeedback to help somebody re-orient their brain."

McIntosh — a professor in SFU's department of biomedical physiology and kinesiology, and B.C. Leadership Chair in Neuroscience and Technology Transfer Across the Lifespan — said there's evidence neurofeedback works for patients with certain disorders, even if there is disagreement over exactly how or why.

As with any mental health treatment however, "There's not a single therapy that's going to work for everybody," he said.

"But it might work for some."

'Brain training'

"Neurofeedback is brain training with the goal of increasing cognitive flexibility," said Victoria psychologist Susan Brock.

Brock, former chair of the Canadian Psychological Association's quantitative electrophysiology section, said healthy brains need to "be able to shift flexibly between states" of mind at appropriate times.

But conditions such as post-traumatic stress disorder (PTSD), one of her specializations, can keep people "in a constant state of over-arousal even when there is no need to be."

That causes a loss of cognitive functioning for such patients, many of whom are emergency first responders and veterans.

A person wears a cap on their head with sensor nodes and wires while watching a display monitor.
Electroencephalogram-guided neurofeedback involves technicians placing electrodes around a patient's head, as seen in this photo, to scan the electrical activity in their brains. Here, the patient is seen watching a display monitor. (Craig Chivers/CBC)

Electroencephalography-guided neurofeedback is offered by a number of private psychiatrists and psychologists across B.C.

The treatment, in simple terms, involves technicians placing electrodes around a patient's head to scan the electrical activity in their brains, known as an electroencephalogram (EEG).

The EEG creates a sort of computer brain map, which can then be used by mental health professionals to help encourage healthier states of mind.

Clinicians use several methods to do this, but often patients watch a video while fitted with the EEG electrodes.

If their brain shows unhealthy or undesirable electrical activity, the video becomes darker and quieter. But when their brainwaves more closely match a "map" of a healthy brain, the video gradually gets brighter and more audible, as their EEG starts to mirror a healthier or calmer brain.

In effect, being able to enjoy a clearer video acts as a type of reward or incentive to calm the mind and, the theory goes, to slowly build healthy patterns.

The unorthodox approach is used more and more among people with a range of mental health conditions from attention deficit hyperactivity disorder (ADHD) to anxiety and post-traumatic stress disorder (PTSD), according to clinicians.

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Brock said she's "seen a good response" in her decades of experience using the treatment. She said her patients often report troubling areas of their lives that "haven't really changed" for the better, despite having tried a variety of mental health therapies before.

Many still struggled with the ability to shift their mind states when needed — for instance, to be able to calm themselves when distressed.

"It's not that they don't want to change," Brock said. "They don't know how.

"And for most, it is not for lack of trying; part of the beauty of neurofeedback training is it happens on a subconscious level."

More data needed

While frontline psychologists and psychiatrists say they see clear clinical improvements in many of their patients, researchers are divided on neurofeedback's efficacy. 

Several peer-reviewed studies suggest better data is needed to prove it works for the wide range of disorders practitioners claim to treat. Evidence appears strongest for ADHD, anxiety disorders, and traumatic brain injuries.

A Basic and Clinical Neuroscience journal article in 2016 found it "is a safe and non-invasive procedure that showed improvement in the treatment of many problems and disorders" including ADHD, anxiety, depression, and autism.

But, the authors cautioned, "its validity has been questioned in terms of conclusive scientific evidence of its effectiveness."

Another study, in the journal Psychiatric Clinics of North America, compared multiple neurofeedback trials, finding they produced "significant benefits" for ADHD and anxiety and were "probably efficacious" for traumatic brain injuries and substance use.

But the researchers said "despite findings of positive outcomes" for depression and PTSD, evidence remains "insufficient" without more rigorous or larger scientific studies.

Best combined with other treatments

For frontline clinicians, the results are in front of their eyes — and in their patients' experiences.

Four years ago, psychiatrist Dr. Kourosh Edalati founded Elumind Centres For Brain Excellence, which has private clinics in North Vancouver, Langley and Kelowna. He offers neurofeedback, alongside more conventional psychotherapy and medications.

"As an integrated model, we've seen very, very good responses," he said. "The principle behind neurofeedback is really operant conditioning … which means positive and negative reinforcement.

"The brain learns that connecting to the right pathway is rewarding. Through all the repetition, the brain starts to switch to the right pathways."

A skullcap covered in sensor nodes and wires is placed on a person's head.
Test person Niklas Thiel poses with an electroencephalography (EEG) cap which measures brain activity, at the Technische Universitaet Muenchen (TUM) in Garching near Munich in September 2014. (Reuters)

By taking a multi-pronged approach to treatment, said SFU's McIntosh, neurofeedback is likely best combined with other methods.

"We have to be very cautious to not think, 'I'm just going to get brain stimulation that'll make me better,'" he said. "Some people need additional support."

"It does seem to work for some people ... allowing people to get unstuck."

But he said precisely how neurofeedback achieves that in the brain remains unproven.

"Why are these things working?" he said. "The 'how' of it is a bit of a mystery.

"The evidence is pretty good — but not conclusive."

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The Winnipeg Foundation Innovation Fund supports cutting-edge projects - UM Today

February 1, 2024 —  Three interdisciplinary teams from the Rady Faculty of Health Sciences have received $100,000 grants from The Winnipeg...